Tham Pham Thi, Thuy Giang Le Nhat, Thuong Ngo Hanh, Tan Luc Quang, Chinh Pham The, Tuyet Anh Dang Thi, Ha Thanh Nguyen, Thu Ha Nguyen, Phuong Hoang Thi, Tuyen Van Nguyen.
Abstract
The synthesis of various substituted triazole–indenoisoquinoline hybrids was performed based on a CuIcatalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl)propargylindenoisoquinolines was used as substrates forthe construction of triazole–indenoisoquinoline–AZT conjugated via a click chemistry-mediated couplingwith 30-azido-30-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazolehybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticanceractivity of four triazole linker–indenoisoquinoline–AZT hybrids in KB and HepG2 cancer cell lines.
2016 Elsevier Ltd. All rights reserved.
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